The Cowboys reeled off 10 straight points to regain lead in upset bid over Cyclones.
The Oklahoma St. Cowboys trailed Iowa State after the first quarter, but scored 10 unanswered points in the second quarter to take a 17-10 lead at the half.
Oklahoma St. had a chance to extend their lead late in the second quarter, but Josh Stewart was stripped by Deon Broomfield at the Iowa State 3-yard line, giving the Cyclones the ball back when the Cowboys looked like they were about to blow the game open. Broomfield's 43-yard return was called back when it was ruled that his knee was down at the 3-yard line.
Cyclones quarterback Jared Barnett has 169 yards passing on 16-of-28 passing with one touchdown and 32 yards rushing.
The Cowboys are looking for the upset over the 24th-ranked Cyclones.