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The Cowboys are the latest team hoping to take advantage of playing the worst team in the Big 12 as Oklahoma State visits the Kansas Jayhawks.
It wasn't pretty last year when Oklahoma State took on Kansas.
Quarterback Brandon Weeden threw five touchdowns by the second quarter, and was taken out of what was eventually a 70-28 home victory.
The quarterback who replaced him, J.W. Walsh, will be under center again. Kansas (1-4, 0-2 Big 12) is coming off a 56-16 loss at Kansas State, their fourth consecutive defeat.
Keeping pace with the Cowboys' high-scoring offense will be a challenge for the Jayhawks, who are surrendering 29.6 points a game. Oklahoma State is averaging 55.8 points a game, scoring at least 36 points in their first four games.
Oklahoma State is coming off a tough 41-36 loss at Texas on Sept. 29, and had a week off to prepare for Kansas.
The Cowboys are favored by 21 points over the host Jayhawks.
Kickoff is set for 2:30 p.m. CT in Lawrence, Kan., and will be televised on FSN.