Russell Westbrook had his fourth consecutive 20-point game versus Philadelphia on Friday.
Westbrook also committed six turnovers and has now turned the ball over 12 times in the last two games.
The Thunder shot 52.0 percent from the floor and were 10-of-17 from three-point territory as a team while holding the 76ers to just 40.5 percent shooting from the field.
Jrue Holliday led Philadelphia with 15 points and nine assists on 7-of-13 shooting from the field.
The loss was Philadelphia's second in a row as they fell to 15-19 on the season. Oklahoma City improved to 25-7 with the win.