A shocking result capped Wednesday's play at the U.S. Open, as No. 6 Tomas Berdych upset top-seed Roger Federer, 7-6, 6-4, 3-6, 6-3. Berdych came out firing and held on to his early two-sets-to-none lead.
Federer's loss marks the first time in 11 years the men's No. 1 seed has not advanced to the semifinals, and is also his first ever night loss at the U.S. Open.
Also on the men's side, No. 3 Andy Murray beat Marin Cilic in four sets in a quarterfinal match. After dropping the first set 3-6, the Olympic gold medalist won the next three 7-6, 6-2, 6-0. Murray will face the upset-minded Berdych.
Earlier in the day, Roddick fell to Juan Martin del Potro 6-7, 7-6, 6-2, 6-4. The loss marks the final match for the 30-year-old Roddick, who is retiring after hitting 16 more unforced errors than the Argentinian. Del Potro advances to the quarterfinals to face No. 2 Novak Djokovic, who dispatched of Switzerland's Stanislas Wawrinka, 6-4, 6-1, 3-1, as Wawrinka retired in the third set.
On the women's side, favorites Maria Sharapova and Serena Williams both won their quarterfinal matches. Williams made quick work of Ana Ivanovic, 6-1, 6-3, to advance to the semis where she will face No. 10 Sara Errani of Italy. The third-seeded Sharapova defeated Marion Bartoli 3-6, 6-3, 6-4, and is set to face top-seed Victoria Azarenka in the semis.