Line: 49ers are favored by three.
RB Jamaal Charles
Though Charles has just 22 carries to Thomas Jones' 33, there are some wondering if this will be the game Charles really comes out. The 49ers are stout in the middle of their defense. The Chiefs have said they're going to give their backs carries based on the best match-up. Jones excels running between the tackles or where the 49ers are strong.
Perhaps the Chiefs strength against the 49ers will be outside the tackles, where Charles excels.
Prediction: 85 rushing yards, 30 receiving yards, 1 touchdown