McFadden, Oakland's erstwhile workhorse, has been out for much of 2011 with a nagging foot injury, and though he was jogging at practice this week, he has yet to make a return to practice.
That means that the Raiders are likely to rely on their revived passing game against Kansas City. But Carson Palmer will be without Jacoby Ford, and Louis Murphy, Denarius Moore, and Chaz Schilens all make their way onto the Raiders' injury report.
Here's the rest of the Raiders injury report for Week 16:
OUT: CB Stanford Routt (knee), QB Jason Campbell (collarbone), WR Jacoby Ford (foot), DT John Henderson (knee), S Michael Huff (hamstring), RB Darren McFadden (foot).
QUESTIONABLE: RB Michael Bush (shoulder), RB Taiwan Jones (hamstring), WR Louis Murphy (groin).
PROBABLE: RB Rock Cartwright (calf), S Matt Giordano (shoulder), CB Bryan McCann (concussion), WR Denarius Moore (foot), C Samson Satele (shoulder), WR Chaz Schilens (hip), DT Tommy Kelly (toe).