McCluster did not practice on Wednesday but had full participation on Friday, with coach Romeo Crennel saying the receiver will play against the Panthers on Sunday. In 11 games this season the receiver has 334 yards receiving on 38 catches and one touchdown.
Tackle Albert Branden (back), linebacker Tamba Hali (knee) and guard Ryan Lilja (knee) were all listed as questionable for the game. Lilja and Hali are both expected to play, while Albert's status at game time is still uncertain.
Safety Kendrick Lewis is doubtful against the Panthers after suffering a shoulder injury against Denver and is not expected to play after missing practice all week.
The Chiefs welcome the Panthers to Arrowhead Stadium on Sunday, with kickoff set for 12 p.m. CT and coverage on Fox.