The differences between the offenses of Kansas City's opponents - Atlanta in Week 1 and Buffalo in Week 2 - couldn't be more contrasting. The Falcons lit the Chiefs up for 40 points, while Buffalo turned the ball over four times in a 48-28 loss at the Jets.
Does that give the Chiefs more of an advantage when they go on the road to Buffalo? Some say yes.
Arrowhead Pride's Joel Thorman is siding with the hometown Chiefs, picking a 27-23 win for Kansas City.
Nine of the 12 writers on ESPN's NFL picks panel are taking the Chiefs as well. Merril Hoge, Ron Jaworski and Cris Carter are upsetting the apple cart by taking the Bills.
CBS, on the other hand, is going on the other direction. Six of their eight panelists are going with Buffalo, as only Jason LaCanfora and Ryan Wilson selected the Chiefs.
Sound off on who you think will win for each team by clicking on Arrowhead Pride for the Chiefs or Buffalo Rumblings for the Bills. You can check out SB Nation's total league coverage by reading its NFL Hub.