However, the loss of Jackson may not be as big a loss for Buffalo as expected, with backup C.J. Spiller ready to pick up the slack against the Chiefs. Via the Associated Press:
Spiller, the ninth overall pick out of Clemson in the 2010 draft, will once again be thrust into the starting role in Buffalo's backfield when the Bills (0-1) host Kansas City (0-1) Sunday. With starter Fred Jackson out with a knee injury sustained in last week's loss to the Jets, the rushing load will be squarely on Spiller's shoulders for at least the next month.
Spiller shined late last season after Jackson broke his leg against Miami in Week 11, averaging almost 90 yards rushing in the team's last three games. His 757 yards from scrimmage since Week 13 of last year is fourth-most in the NFL.
Kickoff is scheduled for noon CT on CBS. Spero Dedes and Steve Beuerlein have the call.
Sound off on who you think will win for each team by clicking on Arrowhead Pride for the Chiefs or Buffalo Rumblings for the Bills. You can check out SB Nation's total league coverage by reading its NFL Hub.