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It wasn't pretty last year when Oklahoma State took on Kansas.
Quarterback Brandon Weeden threw five touchdowns by the second quarter, and was taken out of what was eventually a 70-28 home victory.
The quarterback who replaced him, J.W. Walsh, will be under center again. Kansas (1-4, 0-2 Big 12) is coming off a 56-16 loss at Kansas State, their fourth consecutive defeat.
Keeping pace with the Cowboys' high-scoring offense will be a challenge for the Jayhawks, who are surrendering 29.6 points a game. Oklahoma State is averaging 55.8 points a game, scoring at least 36 points in their first four games.
Oklahoma State is coming off a tough 41-36 loss at Texas on Sept. 29, and had a week off to prepare for Kansas.
The Cowboys are favored by 21 points over the host Jayhawks.
Kickoff is set for 2:30 p.m. CT in Lawrence, Kan., and will be televised on FSN.