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Oklahoma State Vs. Missouri Score Update: Weeden's 3 TD's Give The Cowboys 21-3 Advantage

Three touchdown passes from seasoned veteran quarterback Brandon Weeden has given the No. 4 ranked Oklahoma State Cowboys a 21-3 lead over the Missouri Tigers in Columbia.

Touchdown catches by Michael Harrison (27 yards) Justin Blackmon (8 yards) and Joseph Randle (13 yards) capped off lengthy drives by the Cowboys as Weeden conducted scoring drives of 74 yards and 88 yards in just under three minutes each in the first quarter. Randle's TD catch has kicked off the second quarter as Weeden's stat line is an astounding one, 20-26 passing for 229 yards and 3 TD's.The 2010 Biletnikoff winner Blackmon has 7 catches.

Missouri's best drive came midway through the first quarter as big chunks in the passing game, some razzle-dazzle (a halfback pass from Josey to James Franklin) and a few runs got the Tigers on the board with a field goal from the shaky kicker Grant Ressel.

Oklahoma State's defense has played well thus far, forcing three punts and the lone field goal.