Syracuse quarterback Ryan Nassib spoiled Missouri's party with a 17-yard touchdown in the waning seconds of the game to give the Orange a 31-27 win over the Tigers.
It was the Tigers final home game of the season, with only a game at Texas A&M left on the schedule. Missouri needs a win to become bowl eligible for the eighth straight season.
Nassib had no qualms with spoiling the home crowd's mood however, calling it a special win considering the bowl implications for Syracuse now.
"It was fun; we have fun silencing crowds like this. We have been there before and fortunate enough to make the plays to put us ahead."
It was a big game for Nassib who was 26-for-40 for 385 yards and two touchdowns. He set the Syracuse career record for passing yards and with the win the Orange are now bowl eligible.
Missouri head coach Gary Pinkel said it was a tough loss to swallow; especially considering it was senior night.
"This is a difficult loss, but we have to wake up and get going. It's always difficult, but we have to get up and go back and battle. Obviously we're playing a very good football team that's on a roll and has had a great year."
Texas A&M, the Tigers final opponent of the 2012 season, is coming off of a victory over Sam Houston State on Saturday.